The role of the blood-brain barrier in the aetiology of permanent brain dysfunction in hyperphenylalaninaemia
โ Scribed by F. A. Hommes
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 487 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0141-8955
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The bloodโbrain barrier (BBB) regulates the passage of molecules between the bloodstream and the brain. Overcoming the difficulty of delivery drugs to specific areas of the brain is a major challenge. The BBB exerts a neuroprotective function as it hinders the delivery of diagnostic and
Pericytes are a very important cellular constituent of the blood-brain barrier. They play a regulatory role in brain angiogenesis, endothelial cell tight junction formation, blood-brain barrier differentiation, as well as contribute to the microvascular vasodynamic capacity and structural stability.
## Abstract Alzheimer's disease (AD) is a neurodegenerative disease that leads to a progressive loss of integrative and memory capacities of the brain. This is the predominant form of neurodegenerative dementia, with a growing prevalence of between 1 in 50 and 1 in 100 in North America. Numerous hy