Immediate and long-lasting effects of MK
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Ian Q. Whishaw; Roland N. Auer
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Article
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1989
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Springer
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English
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In a series of experiments, rats received the noncompetitive N-methyl-B-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impa