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The Role of the AP-1 Transcription Factors c-Fos, FosB, Fra-1 and Fra-2 in the Invasion Process of Mammary Carcinomas

✍ Scribed by Karin Milde-Langosch; Heike Röder; Birte Andritzky; Bahriye Aslan; Gabriele Hemminger; Anja Brinkmann; Christoph M. Bamberger; Thomas Löning; Ana-Maria Bamberger

Book ID: 111575085
Publisher: Springer US
Year: 2004
Tongue: English
Weight: 302 KB
Volume: 86
Category: Article
ISSN: 0167-6806
DOI: 10.1023/b:brea.0000032982.49024.71

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Administration of convulsant doses of Metrazole (pentylenetetrazol) and picrotoxin, as well as maximal electroshock, results in a rapid but transient increase in c-fos mRNA in mouse brain. Elevation of c-fos mRNA is followed by the accumulation and subsequent disappearance of Fos, the protein encode