Human cerebral cortical synaptosomes were used to determine the 5-hydroxytryptamine (5-HT) receptor subtype to which the inhibitory presynaptic 5-HT autoreceptor belongs. The synaptosomes preincubated with [3H~5-HT were superfused and tritium overflow was stimulated by high K +. The K +-evoked triti
β¦ LIBER β¦
The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig
β Scribed by Ian A Pullar; John R Boot; Richard J Broadmore; Tina A Eyre; Jane Cooper; Graham J Sanger; Susan Wedley; Stephen N Mitchell
- Book ID
- 113584721
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 299 KB
- Volume
- 493
- Category
- Article
- ISSN
- 0014-2999
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The 5-HT, agonist 2-methyl-5-HT had previously been shown to enhance the electrically evoked release of L3Hl5-HT from preloaded slices of the guinea pig brain. In the present study, 2-methyld-HT (1 pM) was also found to increase the K' evoked release of i3HI5-HT from preloaded slices of the guinea p