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The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro

✍ Scribed by Sara E. Lambard; Alan K. Burnett; C.Roland Wolf; John A. Craft


Book ID
115782266
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
951 KB
Volume
42
Category
Article
ISSN
0006-2952

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7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) t o electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of