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The Role of Second-Generation Antifungal Triazoles for Treatment of the Endemic Mycoses

✍ Scribed by Alison G. Freifeld; J. Ryan Bariola; David Andes


Book ID
107542839
Publisher
Springer
Year
2010
Tongue
English
Weight
170 KB
Volume
12
Category
Article
ISSN
1523-3847

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## Abstract A series of __O__‐alkyl iminoxylitol derivatives was synthesized and evaluated as β‐glucocerebrosidase (GCase) inhibitors. This structure–activity study shows a dramatic influence of the position of the alkyl chain (α‐C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2‐shift o