The role of retinoblastoma protein in apoptosis
β Scribed by G. Fan; C. J. Steer
- Book ID
- 110277377
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 194 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1360-8185
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Previously we reported that at the onset of apoptotic execution, retinoblastoma protein (RB) was cleaved in its interior region, resulting in production of two major fragments, p48 and p68, and that the RB interior cleavage was mediated by a caspase-like activity. Here, we further characterized the
## Abstract The retinoblastoma protein (pRb105) is a true tumor suppressor as deregulation of the Rb pathway by either mutation of pRb105 itself or other proteins in the pathway, such as p16INK4a, occur in most cancers. This prototypical family member, along with the related p107 and p130, are invo