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The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts

โœ Scribed by Linhart, Kirsten; Bartsch, Helmut; Seitz, Helmut K.


Book ID
126968540
Publisher
Elsevier
Year
2014
Tongue
English
Weight
980 KB
Volume
3
Category
Article
ISSN
2213-2317

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Cytochrome P-450 2E1 is a specific isozyme of cytochrome P-450 induced by ethanol. P-450 2E1 may also be the only enzyme that metabolizes N-nitrosodimethylamine at a very low concentration. Because N-nitrosodimethylamine is a procarcinogen, the possibility that induction of P-450 2El by alcohol abus