The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation

Factors that restrict intestinal cell pe

Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa

✍ Hui Ouyang; Weiqing Chen; Thomas E. Andersen; Bente Steffansen; Ronald T. Borcha 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

The objective of this study was to determine the relative importance of metabolism by cytochrome P450 (CYP) enzymes versus efflux by P-glycoprotein (P-gp) in restricting the intestinal mucosal permeation of cyclic prodrugs (AOA-DADLE, CA-DADLE, OMCA-DADLE) of the opioid peptide DADLE (H-Tyr-D-Ala-Gl