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The Role of Protein p16INK4ain Glottic Laryngeal Squamous Cell Carcinoma

✍ Scribed by Kalfert, David; Celakovsky, Petr; Laco, Jan; Ludvikova, Marie

Book ID: 125379752
Publisher: Springer Netherlands
Year: 2014
Tongue: English
Weight: 409 KB
Volume: 20
Category: Article
ISSN: 1219-4956
DOI: 10.1007/s12253-014-9773-y

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## Abstract The __p16__^INK4a^ gene, localized within chromosome 9p21, has been identified as a cyclin‐dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series