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The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

โœ Scribed by Barbara M.A. Lussenburg; Peter H.J. Keizers; Chris de Graaf; Mats Hidestrand; M. Ingelman-Sundberg; Nico P.E. Vermeulen; Jan N.M. Commandeur


Book ID
113487691
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
245 KB
Volume
70
Category
Article
ISSN
0006-2952

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๐Ÿ“œ SIMILAR VOLUMES


Roles of phenylalanine at position 120 a
โœ Kazufumi Masuda; Keietsu Tamagake; Takashi Katsu; Fumihiro Torigoe; Keita Saito; ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 350 KB

## Abstract The roles of Pheโ€120 and Gluโ€222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wildโ€type CYP2D6 (CYP2D6โ€WT) oxidized BTL to 4โ€hydroxybunitrolol (4โ€OHโ€BTL) with substrate enantioselectivity of (__R__)โ€(+)โ€BTL > (__S__)โ€(โˆ’)โ€BTL. The sam