The role of perturbations, shunts, cusps and convexity reversals in elucidating enzyme kinetic mechanisms and hysteresis pathways
✍ Scribed by Robert D. Tanner
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 789 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0009-2509
No coin nor oath required. For personal study only.
✦ Synopsis
Irregular perturbations and convexity reversals m enzyme kmetlc reactlons are mathematlcally modeled by mhlbltlon, catalytic, and rearrangement reactlons The convexity reversal model 1s especially mterestmg smce It offers a simple alternative to the conformational argument of allosterlsm and the subumt coupling notion inherent to the Hill equation Another unusual pattern, a cusp-hke mtersectlon on a fermentation hysteresis traJectory, IS tentatively attributed to enzyme denaturatlon countenng enzyme productlon The role of convexity m reaction schemes where Intermediate concentrations are not measured IS also discussed It 1s proposed that negative convexity m an early reaction rate transient IS a clue to the presence of a shuntmg pathway m the chemical mechanism