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The role of Pbx1 in T cells

✍ Scribed by Mayami Sengupta; Laurence Morel


Book ID
107692184
Publisher
SP Higher Education Press
Year
2011
Tongue
English
Weight
73 KB
Volume
2
Category
Article
ISSN
1674-800X

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## Abstract Pre‐B cell leukemia transcription factors (PBXs) are important co‐factors for the transcriptional regulation mediated by a number of Hox proteins during embryonic development. It was previously shown that the expression of several __Pbx__ genes is elevated in mouse embryo limb buds and

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## Abstract __Hox__ genes contain a homeobox encoding a 60‐amino acid DNA binding sequence. The __Hoxa1__ gene (__Hox1.6__, __ERA1__) encodes two alternatively spliced mRNAs that encode distinct proteins, one with the homeodomain (Hoxa1‐993), and another protein lacking this domain (Hoxa1‐399). The