The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats
β Scribed by S. E. McCONKEY; D. M. GRANT; A. E. CRIBB
- Book ID
- 108885415
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 411 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0140-7783
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## Abstract __p__βAminophenol (PAP) is a widely used industrial chemical and a known nephrotoxin. Recently, it was found to also cause hepatotoxicity and glutathione (GSH) depletion in mice. The exact mechanism of liver toxicity is not known. The aims of this study were to determine whether PAP can
Research into the pathogenesis of acetaminophen (paracetamo1)-induced hepatotoxicity has concentrated on the generation of toxic metabolites by the hepatocytes. It has, however, recently been shown that human macrophages cultured with acetaminophen secrete increased quantities of tumour necrosis fac