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The Role of Organic Anion–Transporting Polypeptides and Their Common Genetic Variants in Mycophenolic Acid Pharmacokinetics

✍ Scribed by Picard, N; Yee, S W; Woillard, J-B; Lebranchu, Y; Le Meur, Y; Giacomini, K M; Marquet, P

Book ID
109845795
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
218 KB
Volume
87
Category
Article
ISSN
0009-9236

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Role of organic anion transporting polyp
Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and β-methyldigoxin in rats
✍ Sachiyo Funakoshi; Teruo Murakami; Ryoko Yumoto; Yoshie Kiribayashi; Mikihisa Ta 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB

Recently, we found that potent P-glycoprotein (P-gp) inhibitors, such as verapamil and cyclosporin A, markedly modulated the pharmacokinetics of digoxin in rats, whereas they did not affect b-methyldigoxin pharmacokinetics significantly. Digoxin is also a substrate of rat organic anion transporting