The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI
β Scribed by Jianhua Zhao; Jonathan P. Bradfield; Mingyao Li; Kai Wang; Haitao Zhang; Cecilia E. Kim; Kiran Annaiah; Joseph T. Glessner; Kelly Thomas; Maria Garris; Edward C. Frackelton; F. George Otieno; Julie L. Shaner; Ryan M. Smith; Rosetta M. Chiavacci; Robert I. Berkowitz; Hakon Hakonarson; Struan F.A. Grant
- Book ID
- 109969597
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 146 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1930-7381
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## Abstract Though multiple interacting loci are likely involved in the etiology of complex diseases, early genomeβwide association studies (GWAS) have depended on the detection of the marginal effects of each locus. Here, we evaluate the power of GWAS in the presence of two linked and potentially