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The role of nucleotide excision repair of Escherichia coli in repair of spontaneous and gamma-radiation-induced DNA damage in the lacZα gene

✍ Scribed by Gitta K Kuipers; Ben J Slotman; Hester A Poldervaart; Ingrid M.J van Vilsteren; Carola A Reitsma-Wijker; M.Vincent M Lafleur


Book ID
117614391
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
90 KB
Volume
460
Category
Article
ISSN
0921-8777

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr