✦ LIBER ✦

The role of noninferiority designs in clinical research

✍ Scribed by Lora Giangregorio; Richard J. Cook

Book ID: 109144091
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 108 KB
Volume: 48
Category: Article
ISSN: 0372-1248
DOI: 10.1111/j.1537-2995.2008.01714.x

No coin nor oath required. For personal study only.

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## Abstract In self‐designing clinical trials, repeated confidence intervals are derived for the parameter of interest where the results of the independent study stages are combined using the generalized inverse chi‐square‐method. The confidence intervals can be calculated at each interim analysis