The role of nitric oxide in the kainate-induced seizures in mice
✍ Scribed by PrzegaliÅski, Edmund; Baran, Leokadia; Siwanowicz, Joanna
- Book ID
- 121317244
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 295 KB
- Volume
- 170
- Category
- Article
- ISSN
- 0304-3940
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We assessed the effects of N(omega)-nitro-L-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on behavioral and electrographic seizures elicited in mice by convulsant doses of kainate. In Expt. 1, L-NAME dose-dependently potentiated the convulsant effects of kainate (44 mg
Both insulin, depending on the glycemic state, and nitric oxide (NO), depending on the experimental conditions, have been suggested to have either proconvulsant or anticonvulsant effects. It is also known that NO plays an important role in some of the peripheral effects of insulin. The aim of the pr