Role of nitric oxide in acetaminophen-in
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Carol R. Gardner; Diane E. Heck; Chung S. Yang; Paul E. Thomas; Xu-Jie Zhang; Ge
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Article
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1998
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John Wiley and Sons
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English
β 199 KB
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Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that cytotoxic mediators produced by pa