The Hepatotoxicity of Valproic Acid and
โ
G. Richard Granneman; Shyh-Ing Wang; James W. Kesterson; Joseph M. Machinist
๐
Article
๐
1984
๐
John Wiley and Sons
๐
English
โ 685 KB
The role of metabolites in valproic acid (VPA)-associated hepatotoxicity was studied in rats. The most steatogenic mono-unsaturated metabolite, 4-en-VPA, caused the greatest changes in indicators of beta-oxidation inhibition (dicarboxylic aciduria, beta-hydroxybutyrate reduction); however, the bioch