## Abstract The most common NF1 feature is the benign neurofibroma, which consists predominantly of Schwann cells. Dermal neurofibromas usually arise during puberty and increase in number throughout adulthood. Plexiform neurofibromas, associated with larger nerves, are often congenital and can be l
The role of NF1 in Schwann Cell development and tumor formation and the influence of steroid hormones and metabolites
β Scribed by Therese M. Roth; Poornapriya Ramamurthy; Fumi Ebisu; Kate F. Barald
- Book ID
- 116976444
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 54 KB
- Volume
- 306
- Category
- Article
- ISSN
- 0012-1606
No coin nor oath required. For personal study only.
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## Abstract Plexiform neurofibromas are peripheral nerve sheath tumors that arise frequently in neurofibromatosis type 1 (NF1) and have a risk of malignant progression. Past efforts to establish xenograft models for neurofibroma involved the implantation of tumor fragments or heterogeneous primary