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The role of neurofibromin in N-Ras mediated AP-1 regulation in malignant peripheral nerve sheath tumors

✍ Scribed by Janice M. Kraniak; Daochun Sun; Raymond R. Mattingly; John J. Reiners; Michael A. Tainsky


Publisher
Springer
Year
2010
Tongue
English
Weight
364 KB
Volume
344
Category
Article
ISSN
0300-8177

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Neurofibromatosis type-1 (NF1) is associated with the growth of benign and malignant tumors. Approximately 15% of NF1 patients develop malignant peripheral nerve sheath tumors (MPNSTs), underlining the need to identify specific diagnostic/prognostic biomarkers associated with MPNST development. The