The role of mycophenolate mofetil in kidney transplantation revisited
β Scribed by Maripuri, Saugar; Kasiske, Bertram L.
- Book ID
- 122323328
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 494 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0955-470X
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π SIMILAR VOLUMES
Mycophenolate mofetil (MM) is the ester derivative of mycophenolic acid (MPA), which exerts immunosuppressive activity by inhibiting de novo purine biosynthesis. Following animal models and pilot studies in human renal allograft recipients that confirmed MM's ability to prevent and half rejection ep
## Background: Steroids have been shown to induce the hepatic glucuronyltransferase (gt) expression enhancing the activity of uridine diphosphate-gt, the enzyme responsible for mycophenolic acid (mpa) metabolism. the impact of steroids on mpa pharmacokinetics, however, has not been investigated to