𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The role of monovalent cations in the interaction between the cytotoxic T lymphocyte and its target

✍ Scribed by John H. Russell; Claraine B. Dobos

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
420 KB
Volume
11
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Evidence is provided for the participation of monovalent cations in both the binding and lytic phases of the lytic cycle. There appears to be one sodium requirement in the cytotoxic T lymphocyte‐target binding event (effective dose~50~ ∼ 35 mM) and possibly another sodium requirement in the delivery of the lethal hit (ED~50~ <7 mM). Potassium can replace sodium in the binding event but antagonizes the lethal hit phase (inhibitory dose~50~ ∼ 110 mM). Lithium antagonizes the binding event (ID~50~ ∼ 15 mM).

πŸ“œ SIMILAR VOLUMES

Qualitative difference between the cytot
Qualitative difference between the cytotoxic T lymphocyte responses to melanocyte antigens in melanoma and vitiligo
✍ Belinda Palermo; Silvia Garbelli; Stefania Mantovani; Elisabetta Scoccia; Gian A πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 253 KB

Vitiligo is a skin disorder characterized by depigmented macules secondary to melanocyte loss. An unusual facet is its relation to melanoma: Cytotoxic T lymphocytes directed to melanocyte antigens are found in both conditions and imply a breakdown of tolerance, yet the resulting immune reaction is t