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The role of mitochondrial permeability transition in reperfusion-induced cardiomyocyte death depends on the duration of ischemia

✍ Scribed by Marisol Ruiz-Meana; Javier Inserte; Celia Fernandez-Sanz; Victor Hernando; Elisabet Miro-Casas; Ignasi Barba; David Garcia-Dorado

Publisher: Springer
Year: 2011
Tongue: English
Weight: 437 KB
Volume: 106
Category: Article
ISSN: 0300-8428
DOI: 10.1007/s00395-011-0225-5

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## Abstract Hepatic encephalopathy (HE) is a major neurological complication in patients with severe liver disease. While the pathogenesis of HE is unclear, elevated blood and brain ammonia levels are believed to be major etiological factors, and astrocytes appear to be the primary target of its to