The role of membrane water permeability in characterization of pathologically altered human stomach tissues: NMR studies
✍ Scribed by Radivoje Srejić; Danica V. Popov; Ivan Boričić; Marinki Žuvela
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 263 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Comparative NMR studies of normal and pathologically altered human stomach tissues were performed on the basis of proton T~1~ relaxation time measurements in the presence of high external concentrations of relaxation (contrast) agents manganese ethylenediaminetetraacetic acid (Mn‐EDTA) and gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA). Diffusion permeability of the cell membrane to water, P~d~, was determined by measuring the longest proton T~1~ component sensitive to the exchange of water molecules through the cell membrane. Pathologically altered tissues showed substantially higher (2 to 10 times) average cell membrane permeabilities to water. © 1990 Academic Press, Inc.