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The role of membrane composition in ATPase activities of cirrhotic rat liver: Effect of silymarin

✍ Scribed by Pablo Muriel; Marisabel Mourelle

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 409 KB
Volume: 10
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550100409

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✦ Synopsis

Key wordc cirrhiws, ATPase?. cell plasma membrane, liver, silyinarin. carbon tetrachloride

The activities of Ca2+and Na + , K'-ATPases were studied in liver plasma membranes from CCI,-cirrhotic rats and from livers of rats treated with silymarin in addition to CC14. CCIJ chronic treatment produced significant decreases in Na ', K+and Ca2 +-ATPase activities; however, the animals treated with silymarin abng with CCI4 showed no differences in ATPase activities as compared to controls. The lipid analysis performed in plasma membranes revealed increases in the cholesterollphospholipid (CHIPL) and sphingomyelinlphosphatidylcholine (SM/PC) ratios in the cirrhotic group. Again, the membranes isolated from rats receiving CCIJ + silymarin showed normal CH/PL and SM/PC values. Considering that CHlPL and SMlPC ratios are related to membrane microviscosity, this study suggests that a lower fluidity of the membrane may be responsible for the observed decreases in ArPase activities in the cirrhotic group. Additionally, the role of silymarin to improve liver function in CC'I,-cirrhosis can be attributed partially to its action at membrane level by preventing the increases in CW/PL and SM/PC ratios.

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