𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The role of kupffer cells in rat liver regeneration revealed by cell-specific microarray analysis

✍ Scribed by Cun-Shuan Xu; Yun Jiang; Lian-Xing Zhang; Cui-Fang Chang; Gai-Ping Wang; Rui-Jia Shi; Yan-Jie Yang

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
563 KB
Volume
113
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Liver regeneration after partial hepatectomy is a process with various types of cells involved. The role of Kupffer cells (KCs) in liver regeneration is still controversial. In this study we isolated KCs from regenerating liver and conducted cell‐specific microarray analysis. The results demonstrated that the controversial role of KCs in liver regeneration could be explained with the expression patterns of TGF‐α, IL‐6, TNF, and possibly IL‐18 during liver regeneration. IL‐18 may play an important role in negative regulation of liver regeneration. The functional profiles of gene expression in KCs also indicated that KC signaling might play a negative role in cell proliferation: signaling genes were down regulated before cell division. Immune response genes in KCs were also down regulated during liver regeneration, demonstrating similar expression profiles to that of hepatocytes. The expression patterns of key genes in these functional categories were consistent with the temporal functional profiles. J. Cell. Biochem. 113: 229–237, 2012. Β© 2011 Wiley Periodicals, Inc.

πŸ“œ SIMILAR VOLUMES

Kupffer cell depletion abolishes inducti
Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver
✍ R M Rai; S Loffreda; C L Karp; S Yang; H Lin; A M Diehl πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 599 KB

that synchronize the regenerative response to liver injury Tumor necrosis factor a (TNF), initiates a cytokine and implies that hepatocytes and liver nonparenchymal cells cascade that promotes hepatocyte proliferation after are both the sources of, and the targets for, various growth-70% partial hep

Inhibition of in vivo rat liver regenera
Inhibition of in vivo rat liver regeneration by 2-acetylaminofluorene affects the regulation of cell cycle-related proteins
✍ Lena C. E. Ohlson; Lena Koroxenidou; Inger Porsch HΓ€llstrΓΆm πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 104 KB πŸ‘ 2 views

The effects of dietary 2-acetylaminofluorene (2-AAF) on cell cycle-related proteins was studied in regenerating livers from male Wistar rats. The levels of cyclins, cyclin dependent kinases (cdks), and related proteins were studied at different times during the first cell cycle after partial hepatec

Suppression of lipopolysaccharide-induce
Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat kupffer cells
✍ Shamimunisa B. Mustafa; Brent D. Flickinger; Merle S. Olson πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 208 KB

Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe

The role of both specific cellular adhes
The role of both specific cellular adhesion and growth promotion in liver colonization by F9 embryonal carcinoma cells
✍ Dario Rusciano; Patrizia Lorenzoni; Max M. Burger πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 816 KB

## Abstract Unselected F9 murine embryonal carcinoma cells preferentially colonize the liver upon injection into tail veins of syngeneic mice, while the lungs are only very rarely colonized. Here we show that F9 cells attach better to fibronectin than to laminin in an adhesion assay, like other liv