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The Role of Iron and Chelators on Infections in Iron Overload and Non Iron Loaded Conditions: Prospects for the Design of New Antimicrobial Therapies

✍ Scribed by Kontoghiorghes, George J.; Kolnagou, Annita; Skiada, Anna; Petrikkos, George


Book ID
118063620
Publisher
Informa plc
Year
2010
Tongue
English
Weight
256 KB
Volume
34
Category
Article
ISSN
0363-0269

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The prospect of selecting oral a-ketohydroxypyrldine chelators Intended for clinical use in iron overload has been examined using several animal models of efficacy and toxicity. Studies using iron dextran-loaded mice labelled with 50Fe have shown that only the 1-substituted methyl, ethyl, (n)propyl,