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The role of interleukin-2 (IL-2) in the specific unresponsiveness of lepromatous leprosy to Mycobacterium leprae: studies in vitro and in vivo

✍ Scribed by Abebe Haregewoin; Jack Longley; Gunnar Bjune; Abu Salim Mustafa; Tore Godal

Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 247 KB
Volume: 11
Category: Article
ISSN: 0165-2478
DOI: 10.1016/0165-2478(85)90175-0

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## Abstract Cholera toxin irreversibly activates a 43‐kDa guanosine triphosphate (GTP)‐binding protein by adenosine diphosphate ribosylation, resulting in activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP). Because increases in intracellular