The role of imprinted genes in humans
β Scribed by Ishida, Miho; Moore, Gudrun E.
- Book ID
- 118033023
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 922 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0098-2997
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In the mouse fetus, Mest is widely expressed in mesoderm derived tissues. In separate studies in mice and in humans, it has been shown to be maternally imprinted, that is, only the paternally inherited allele is active. Here, we show that starting with implantation, Mest is also expressed in materna
## Abstract Epigenetics, and in particular imprinted genes, have a critical role in the development and function of the placenta, which in turn has a central role in the regulation of fetal growth and development. A unique characteristic of imprinted genes is their expression from only one allele,