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The Role of Hydrolysis in the Detoxification of 1,2:3,4-Diepoxybutane by Human, Rat, and Mouse Liver and Lungin Vitro

โœ Scribed by Pieter J. Boogaard; James A. Bond


Book ID
112266293
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
177 KB
Volume
141
Category
Article
ISSN
0041-008X

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The nematocide, grain fumigant, and gasoline additive 1,2-dibromoethane (DBE) is both a cellular and a genetic toxin that is metabolically activated in rats and mice by mixed function oxidases (MFO) as well as glutathione S-transferases (GST). The purpose of this study was to determine whether DBE i