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The role of glutathione in the detoxication of reactive metabolites generated from the carcinogen -hydroxy-2-acetylaminofluorene (N-OH-AAF) in the rat

Book ID
123428769
Publisher
Elsevier Science
Year
1983
Weight
113 KB
Volume
19
Category
Article
ISSN
0277-5379

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The binding of reactive metabolites of t
The binding of reactive metabolites of the carcinogenN-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: Effects of glutathione and methionine
โœ Meerman, John H. N. ;Tijdens, Roeline B. ;Mulder, Gerard J. ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 580 KB

The covalent binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated, intact rat liver nuclei was studied. The chemically synthesized 2-acetylaminofluorene-N-sulfate became covalently bound to DNA and protein to form adducts, 50% to 60% of whi