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The role of glucagon in the regulation of blood glucose: Model studies

✍ Scribed by Ruby Celeste; Eugene Ackerman; Laël C. Gatewood; Clayton Reynolds; George D. Molnar

Publisher
Springer
Year
1978
Tongue
English
Weight
867 KB
Volume
40
Category
Article
ISSN
1522-9602

No coin nor oath required. For personal study only.

✦ Synopsis

Mathematical models afford a procedure of unifying concepts and hypotheses by expressing quantitative relationships between observables. The model presented indicates the roles of both insulin and glucagon as regulators of blood glucose, albeit in different ranges of the blood glucose concentrations. Insulin secretion is induced during hyperglycemia, while glucagon secretion results during hypoglycemia. These are demonstrated by simulations of a mathematical model conformed to data from the oral glucose tolerance test and the insulin infusion test in normal control subjects and stable and unstable diabetic patients. The model studies suggest the parameters could prove of value in quantifying the diabetic condition by indicating the degree of instability.

I. Introduction.

The regulation of the glucose concentration in the blood of humans is one of the basic metabolic functions of the organism. Too low levels (hypoglycemia) may lead to emotional distress, mental confusion and

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