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The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA

✍ Scribed by Dan Eilat

Book ID
118384315
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
941 KB
Volume
27
Category
Article
ISSN
0161-5890

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DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have be