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The role of gastric stasis in tumor-induced anorexia in rats

✍ Scribed by Donna O. McCarthy; Jane M. Dam

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
330 KB
Volume
70
Category
Article
ISSN
0008-543X

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✦ Synopsis

Background:

The current study was undertaken to determine if changes in gastric emptying contribute to tumor-induced anorexia.

Methods:

Rats were implanted with the walker 256 carcinoma, and food intake was measured daily. on days 0, 8, and 15, the rats were fasted overnight, gavage fed a bolus of liquid food, and residual gastric contents were measured 3 hours later.

Results:

Tumor growth was associated with a progressive decline in voluntary food intake. when the rats were gavage fed 2.5 or 7 ml of liquid food, the percent of gastric contents cleared in 3 hours was unchanged with tumor growth.

Conclusions:

Changes in gastric emptying did not contribute to decreased food intake with growth of the walker 256 in rats.

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