The role of FoxC1 in early Xenopus development
β Scribed by J.Y. Cha; B. Birsoy; M. Kofron; E. Mahoney; S. Lang; C. Wylie; J. Heasman
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 700 KB
- Volume
- 236
- Category
- Article
- ISSN
- 1058-8388
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Bone morphogenetic proteins (BMPs) are typically members of the transforming growth factor β€ (TGF-β€) family with diverse roles in embryonic development. At least five genes with homology to BMPs are expressed during Xenopus development, along with their receptors and intracellular signalling pathway
Like mammals, the amphibian Xenopus uses combinatorial joining of the immunoglobulin V, D and J elements and multiple rearrangements to generate its B cell repertoire. Xenopus larvae hatch 2 days after fertilization and individuals are under pressure to develop an immune repertoire when the number o
## Abstract The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. __Foxc1__ encodes a forkhead/winged helix transcription factor required for the development of many embryonic organs. Autosomal dominant mutations in human __FOXC1__ cause eye disorders such as Axen