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The Role of Fatty Acids and Phospholipase IPLA2 in Mitochondrial ATP-Dependent K+ Channel Activity and Cardioprotection

✍ Scribed by Jaburek, Martin; Garlid, Anders O.; Jezek, Petr; Garlid, Keith D.


Book ID
123241697
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
213 KB
Volume
53
Category
Article
ISSN
0891-5849

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While opening of cardiac muscarinic K+ channels is mediated by a guanine nucleotide-binding protein, GK, and normally requires both ACh and cytosolic GTP, we demonstrate that in the absence of agonist and G-nucleotides guinea-pig atrial muscarinic K+ channels are activated by cytosolic ATP (K50 = 22