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The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue

✍ Scribed by Elaine Mutch; Ruediger Nave; Nigel McCracken; Karl Zech; Faith M. Williams

Book ID
113488220
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
298 KB
Volume
73
Category
Article
ISSN
0006-2952

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## Background The nasal tissue uptake and metabolism of ciclesonide, a new-generation corticosteroid under investigation for treatment of allergic rhinitis, to its active metabolite, desisobutyryl-ciclesonide (des-CIC), was evaluated when administered to rabbits in a hypotonic versus an isotonic ci

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## Abstract Ciclesonide is a new‐generation inhaled corticosteroid developed to treat the inflammation associated with persistent asthma. In order to identify the properties of ciclesonide responsible for anti‐inflammatory activity, ciclesonide metabolism was investigated in human lung and liver pr