The role of epigenetic transcription repression and DNA methyltransferases in cancer
✍ Scribed by Filipe Ivan Daniel; Karen Cherubini; Liliane Soares Yurgel; Maria Antonia Zancanaro de Figueiredo; Fernanda Gonçalves Salum
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 306 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. In individuals from high-risk families, mutations in BRCA1 increase the lifetime risk of developing breast cancer eight to tenfold, compared to the general population. How the BRCA1 protein product normally functions
Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a
The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environmen
## Abstract Mutations of BRCA1 gene are associated with more than half the cases of hereditary breast cancer. Breast cancer formation in BRCA1 mutation carriers is generally accompanied by loss of the wild‐type allele, suggesting that BRCA1 protein may function as a tumor suppressor. The human BRCA