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The role of environmental parameters on the stability of cholera toxin functional regions

✍ Scribed by Maurizio Tomasi; Angela Battistini; Clara Ausiello; L.Giorgio Roda; Giuliano D'Agnolo

Book ID
115908974
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
292 KB
Volume
94
Category
Article
ISSN
0014-5793

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The intracellular pathway following receptor-mediated endocytosis of cholera toxin was studied using brefeldin A (BFA), which inhibited protein secretion and induced dramatic morphological changes in the Golgi region. In both mouse Y1 adrcnal cells and CHO cells, BFA at 1 pgiml caused a 80-90% inhib