The process of cancer invasion and metastasis comprises a complex series of sequential steps. The initial step is the dissociation of cancer cells from the primary tumour through the breakdown of the cell adhesion system which includes integrins, selectins, CD44 and the cadherin families of molecule
The role of E-cadherin in the differentiation of gallbladder cancer cells
β Scribed by Shinsuke Mukai; Kohji Miyazaki; Hiroyuki Yakushiji
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 614 KB
- Volume
- 306
- Category
- Article
- ISSN
- 0302-766X
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## Abstract The stabilization of cell surface Eβcadherin is important for the maintenance of apical junction complexes and epithelial polarity. Previously, we reported that discoidin domain receptor 1 (DDR1) forms a complex with Eβcadherin at adhesive contacts; however, the regulatory role of DDR1