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The role of DRAM in autophagy activation and cell death induced by mitochondria dysfunction

✍ Scribed by Zhang, Xingding; Qin, Zhenghong


Book ID
123569086
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
46 KB
Volume
68
Category
Article
ISSN
0168-0102

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## Abstract In vivo administration of the mitochondrial inhibitor 3‐nitropropionic acid (3‐NP) produces striatal pathology mimicking Huntington's disease (HD). However, the mechanisms of cell death induced by metabolic impairment are not fully understood. Previous studies showed that 3‐NP triggered