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The role of disulfide reduction in chromatin release from equine sperm

✍ Scribed by Wagner, Thomas E. ;Mann, David R. ;Vincent, Roger C.

Book ID
102335206
Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
284 KB
Volume
189
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

The induced expulsion of a condensed chromosomal strand from equine sperm head pieces by the combined action of guanidine HCl (0.35M) and β‐mercaptoethanol (5 Γ— 10^βˆ’3^M) is documented by scanning electron microscopy. The circular dichroism spectrum of a disordered gel state of this expelled sperm chromatin is shown and suggests that the DNA component of this chromosomal material may be in the compact Οˆβ€DNA state, The possible role of ‐S‐S‐reductive breakdown in the sperm chromatin expulsion mechanism during fertilization is discussed.

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