The role of death-associated protein kinase (DAPK) in endothelial apoptosis under fluid shear stress

Shear stress regulates expression of dea

Shear stress regulates expression of death-associated protein kinase in suppressing TNFα-induced endothelial apoptosis

✍ Keith Rennier; Julie Y. Ji 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 721 KB

## Abstract Death associated protein kinase (DAPK) is a positive regulator in tumor necrosis factor α (TNFα)‐induced apoptotic pathway, and DAPK expression is lost in cancer cells. In the vasculature, misdirected apoptosis in endothelial cells leads to pathological conditions such as inflammation a