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The role of D1–D2 receptor hetero-dimerization in the mechanism of action of clozapine

✍ Scribed by Agata Faron-Górecka; Andrzej Górecki; Maciej Kuśmider; Zygmunt Wasylewski; Marta Dziedzicka-Wasylewska

Book ID
118436926
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
521 KB
Volume
18
Category
Article
ISSN
0924-977X

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The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do