The role of cytokines in the epithelial cancer microenvironment
β Scribed by Julia Wilson; Fran Balkwill
- Book ID
- 112265063
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 178 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1044-579X
No coin nor oath required. For personal study only.
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A large number of observations point towards cytokines, polypeptides released mainly by immune cells, as the molecules responsible for the metabolic derangements associated with cancer-bearing states. Indeed, these alterations lead to a pathological state known as cancer cachexia which is, unfortuna
## Abstract The tumor microenvironment, composed of nonβcancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining locat