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The role of CpG methylation in cell type-specific expression of the aquaporin-5 gene

✍ Scribed by Johji Nomura; Akinori Hisatsune; Takeshi Miyata; Yoichiro Isohama

Book ID
116294183
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
249 KB
Volume
353
Category
Article
ISSN
0006-291X

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## Abstract The Ξ±2(I) collagen gene shows cell type‐specific expression, however, the mechanism behind this specificity remains to be determined. We demonstrate here that transforming growth factor‐beta (TGF‐β)‐mediated induction of Ξ±2(I) collagen gene is regulated by DNA methylation in a cell type