The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes

Constitutive androstane receptor mediate

Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes

✍ Bingning Dong; Mohammed Qatanani; David D. Moore 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

Untreated type 1 diabetes increases hepatic drug metabolism in both human patients and rodent models. We used knockout mice to test the role of the nuclear xenobiotic receptors constitutive androstane receptor (CAR) and pregnane and xenobiotic receptor (PXR) in this process. Streptozotocin-induced d

Bioactive Terpenoids and Flavonoids from

Bioactive Terpenoids and Flavonoids from Ginkgo Biloba Extract Induce the Expression of Hepatic Drug-Metabolizing Enzymes Through Pregnane X Receptor, Constitutive Androstane Receptor, and Aryl hydrocarbon Receptor-Mediated Pathways

✍ Linhao Li; Joseph D. Stanton; Antonia H. Tolson; Yuan Luo; Hongbing Wang 📂 Article 📅 2008 🏛 Springer US 🌐 English ⚖ 232 KB

ChemInform Abstract: Evaluation of Induc

ChemInform Abstract: Evaluation of Induction of Drug-Metabolizing Enzyme mRNAs in Primary Cultures of Cryopreserved Human and Cynomolgus Monkey Hepatocytes

✍ Masuhiro Nishimura 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 15 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Influence of culture time on the express

Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2

✍ Stefan Wilkening; Augustinus Bader 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 1 views

## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev

Roles of Nuclear Receptors in the Gene E

Roles of Nuclear Receptors in the Gene Expression of Drug-Metabolizing Enzymes under Various Physiological Conditions

✍ Kouichi Yoshinari 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.